Endocrine Abstracts

The mineralocorticoid receptor (MR) is primarily involved in osmoregulation in mammals, with additional roles of brain-behaviour implicated. However, the understanding of this role is limited, partly due to the mortality of MR-knockout mice due to impaired Na+ reabsorption. Many steroidogenesis pathways and hormone receptors are highly conserved in zebrafish, providing a great potential to become a high-throughput model for translational endocrine research. My proje...

Sex development in zebrafish is highly plastic, making this species an ideal model for investigation of endocrine disruption and gonadal development and function. However, the hormonal regulation of these processes in zebrafish is poorly understood. We have used a model of androgen and glucocorticoid deficiency to explore these processes. In humans, ferredoxin (FDX1) is an electron-providing cofactor required for steroid biosynthesis. The zebrafish homologue of FDX1, ...